Xenbase Image ID: 127852

Figure 4. ADP regulation of wild-type and mutant KATP channelsA, mean wild-type (open bar, n= 8) and G1401R (filled bar, n= 7) currents recorded in the presence of 0.1 mm MgATP, 0.1 mm MgADP or 0.1 mm MgATP plus 0.1 mm MgADP. *P < 0.05. B, mean relationships between [ADP] and KATP conductance (G), expressed relative to that in the absence of nucleotide (Gc), for G1401R channels in the absence (o, n= 5) and presence (•, n= 9) of Mg2+. The lines are drawn to eqn (1) with the following parameters: Mg2+-free, IC50= 49 μm, h= 1.3, a= 0.05; with Mg2+, IC50= 105 μm, h= 1.6, a= 0.09. Image published in: de Wet H et al. (2012) Image downloaded from an Open Access article in PubMed Central. © 2012 The Authors. The Journal of Physiology © 2012 The Physiological Society Larger Image Printer Friendly View

Return to previous page