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Figure 6. ATP inhibition of G1401R-KAKA channelsMean relationship between [ATP] and KATP conductance (G), expressed relative to that in the absence of nucleotide (Gc), for Kir6.2/SUR1-G1401R-KAKA channels (o, n= 12). The solution contained Mg2+. The line is drawn to eqn (1) with the following parameters: IC50= 9 μm, h= 1.1, a= 0.03. The lines through the data obtained for Kir6.2/SUR1-G1401R in the absence of Mg2+ (dotted line) and Kir6.2/SUR1-G1401R in the presence of Mg2+ (dashed line) are also shown.

Image published in: de Wet H et al. (2012)

Image downloaded from an Open Access article in PubMed Central. © 2012 The Authors. The Journal of Physiology © 2012 The Physiological Society

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