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Figure 5—figure supplement 3. Genes with TSS-associated testes or liver specific NMIs are over-represented for increased differential expression in the same tissue.MA plots depicting expression differences for genes with TSS-associated NMIs from liver and testes for human, mouse, platypus and chicken. Genes are coloured according to whether they share an NMI in both liver and testes (grey) or have an NMI only in liver (red) or testes (blue). Genes are further distinguished as being differentially expressed or overexpressed in a tissue-specific manner (dark, filled circle) or not (light, open circles). The log mean expression of the gene from both liver and testes is displayed on the x axis (A) and the log ratio of gene expression is displayed on the y axis (M). The dotted lines indicate a fold change threshold of two. Genes with tissue-specific NMIs were significantly over-represented in the set of genes which had increased differential expression in seven out of eight cases (Fisher's exact test, human testes p<10−21, liver p<10−27; mouse testes p<10−18, liver p<10−8; platypus testes p<10−2, liver p<10−17; chicken liver p<10−6).DOI: http://dx.doi.org/10.7554/eLife.00348.011 Image published in: Long HK et al. (2013) Copyright © 2013, Long et al. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Larger Image Printer Friendly View

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