XB-IMG-128749
Xenbase Image ID: 128749
Figure 9. Model of Hif-1 controlling neural crest migration. Neural crest, shown as blue cells, delaminates from the neural tube (NT). Prospective neural crest expresses E-cadherin (E-cad; red), just before EMT Hif-1α activates Twist, which in turn represses E-cadherin expression, allowing neural crest EMT. In addition, Hif-1α activates Cxcr4, which is required for chemotaxis toward SDF-1. Image published in: Barriga EH et al. (2013) © 2013 Barriga et al. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike license Larger Image Printer Friendly View |