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Figure 2. Sox4 or Sox11 loss of function results in an abnormal eye development.Effect of Sox4 (A) and Sox11 (B) depletion on eye development. The injection of Sox4 or Sox11 MO leads to smaller, deformed, and severely deformed eyes (white arrows) as illustrated in a dose dependent manner. A Control MO injection had no effect on eye development. Detailed views demonstrated defects in the formation of the RPE (red arrows). Vibratome sections showed that Control MO injection had no influence on the formation of the retinal layers and the RPE as well whereas depletion of Sox4 or Sox11 resulted in an abnormal RPE and retinal layering (red arrows). Quantitative representations are given. The eye phenotype of Sox4 or Sox11 down-regulation was significantly rescued by the co-injection of either SOX4 or sox11 RNA. GCL = ganglion cell layer, INL = inner nuclear cell layer, n = number of independent experiments, N = number of injected embryos analyzed, ONL = outer nuclear cell layer, RPE = retinal pigment epithelium. Error bars indicate standard error of the means (s.e.m.), * P≤0.05, *** P≤0.001. Image published in: Cizelsky W et al. (2013) Image reproduced on Xenbase with permission of the publisher and the copyright holder. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Larger Image Printer Friendly View

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