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Figure 6. Eye-specific marker genes are unaffected upon loss of Sox4 or Sox11 function.A and B: Depletion of Sox4 function had no influence on marker gene expression at stage 13. Loss of Sox11 led to a slight decrease of pax6 expression. C and D: At stage 23, Sox4 depleted embryos revealed a reduced expression of rax, pax6, sox3 and en2. Emx1 and egr2 expression was not affected. In contrast, all marker genes were mildly affected upon Sox11 knock-down. B and D. Quantitative representations are given. n = number of independent experiments, N = number of injected embryos analyzed, n.s. = not significant, * P≤0.05,** P≤0.01. Image published in: Cizelsky W et al. (2013) Image reproduced on Xenbase with permission of the publisher and the copyright holder. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Gene Synonyms Species Stage(s) Tissue rax.L rax-a, rax-b, rax1, rx, rx-1, rx1, rx1a, Rx2A, Xrax, Xrx1, Xrx1A X. laevis Throughout NF stage 13 optic field pre-chordal neural plate pax6.L an2, mgda, pax-6, pax6-a, pax6-b, wagr, XLPAX6, xpax6 X. laevis Throughout NF stage 13 optic field pre-chordal neural plate chordal neural plate sox3.L Sry, Xlsox3, xSox3, Xtsox3 X. laevis Throughout NF stage 13 neural plate rax.L rax-a, rax-b, rax1, rx, rx-1, rx1, rx1a, Rx2A, Xrax, Xrx1, Xrx1A X. laevis Throughout NF stage 23 optic vesicle pax6.L an2, mgda, pax-6, pax6-a, pax6-b, wagr, XLPAX6, xpax6 X. laevis Throughout NF stage 23 optic vesicle diencephalon neural tube sox3.L Sry, Xlsox3, xSox3, Xtsox3 X. laevis Throughout NF stage 32 brain spinal cord optic vesicle cranial neural crest emx1l.L Xemx1 X. laevis Throughout NF stage 32 forebrain en2.L En-2, en2-a, en2-b, eng2, engrailed 2, engrailed homolog 2, engrailed-2, maben, xen2 X. laevis Throughout NF stage 23 midbrain-hindbrain boundary egr2.L EGR-2, Krox-20, krox20, XKr20, XKrox-20 X. laevis Throughout NF stage 23 rhombomere R3 rhombomere R5 cranial neural crest Image source: Published Larger Image Printer Friendly View

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