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Figure 2. Glutamate-induced currents as a function of glutamate concentration in EAAT3/EAAT4-expressing Xenopus oocytes wihout or with Klotho coexpression.A, C: Means ± SEM of glutamate-induced current (Iglu) as a function of glutamate concentration in Xenopus oocytes injected with cRNA encoding EAAT3 (A, n = 9) or EAAT4 (C, n = 6) without (open circles) or with (closed circles) additional coexpression of Klotho.*,**(p<0.05, p<0.01) indicate statistically significant difference from Xenopus oocytes injected with cRNA encoding EAAT3 (A) or EAAT4 (C) alone (two-tailed unpaired t-test). B, D: Means ± SEM of glutamate induced current (Iglu) normalized to Iglu at 5 mM glutamate as a function of glutamate concentration in Xenopus oocytes injected with cRNA encoding EAAT3 (B, n = 9) or EAAT4 (D, n = 6) without (open circles) and with (closed circles) additional coexpression of Klotho. The values were fitted to a hyperbola function. Image published in: Almilaji A et al. (2013) Image reproduced on Xenbase with permission of the publisher and the copyright holder. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Larger Image Printer Friendly View

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