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Figure 4. Effect of recombinant human β-Klotho protein on electrogenic glutamate transport in EAAT3 -expressing Xenopus oocytes.A: Means ± SEM (n = 7–16) of glutamate (2 mM)-induced current (Iglu) in Xenopus oocytes injected with water (grey bar) or injected with cRNA encoding EAAT3 and pretreated prior to measurements for 24 hours without (white bar) or with 10, 30 and 50 ng/ml recombinant human β-Klotho protein (1st, 2nd and 3rd black bar respectively).*,**(p<0.05, p<0.01) indicate statistically significant difference from untreated Xenopus oocytes (ANOVA). B: Means ± SEM (n = 12–17) of glutamate (2 mM)-induced current (Iglu) in Xenopus oocytes injected with water (grey bar) or injected with cRNA encoding EAAT3 pretreated prior to measurements with 30 ng/ml recombinant human β-Klotho protein for 0 hr (white bar) or 1, 6, 12 or 24hr (black bars respectively).**(p<0.01) indicates statistically significant difference from untreated Xenopus oocytes (ANOVA). Image published in: Almilaji A et al. (2013) Image reproduced on Xenbase with permission of the publisher and the copyright holder. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Larger Image Printer Friendly View

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