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Fig. 3. Impact of rbpj overexpression on the FGF signalling pathways.We injected nLacZ and control or TP MO, or dnRAR mRNA, as indicated, into one blastomere of two-cell embryos, which we allowed to develop until the tailbud stage. Where indicated, we treated the embryos for 2 hours with SU5402 (embryos injected with control MO were treated with DMSO) and we stained them for β-galactosidase activity (red dots) and fgf8 (A), msgn1 (B), or dusp6 (C) mRNA by ISH. We sorted DMSO and SU5402-treated embryos into 5 classes depending on their staining intensities. The right panels show the percentages of embryos within each of these classes, and, for injected embryos, the percentage of embryos with a staining intensity in the injected side above, equal to, and below (respectively green, yellow and red) that in the control side. We compared the distributions, between the classes, of the control and the other conditions by a chi-square test and we show the p-values. All the photographs are dorsal views, anterior left, injected-side up. Image published in: Cibois M et al. (2013) © 2013. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Larger Image Printer Friendly View

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