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Figure 8. Model to simulate induction response.(A) Schematic of the G3 inducible system. This model includes transcription, translation and transport of Rho-mCherry reporter with both nuclear and cytoplasmic mRNA and protein degradation. (B) Simplified model of inducible system. Transcription and translation steps were combined to yield a model with five parameters: variable sinusoidal synthesis of G3, Dex, kact, γcyto and γnuc for degradation (See Appendix S1 for details). (C) Simulation of induction responses to seven Dex treatments. Upper panel shows constant G3 expression and lower panel shows variable G3 expression with 10-day period. Color arrows in left-most panel indicate induction at different phases of a 10-day period. The corresponding average induction responses (Rho expression) are plotted in the corresponding color. These responses were obtained by averaging hundreds of simulations responses with randomized phases. The rightmost plots show how the phase of G3 expression changes the characteristic positions in induction response: rising midpoint (red), peak (purple) and falling midpoint (green). Image published in: Zhuo X et al. (2013) Image reproduced on Xenbase with permission of the publisher and the copyright holder. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Larger Image Printer Friendly View

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