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Figure 2. Depletion of either mef2c or mef2d leads to severe cardiac defects.A, C. Mef2c- or Mef2d MO-injected embryos developed cardiac edema and morphological heart defects at stage 42, as compared with Control MO-injected sibling embryos. The amount of MO injected in total (two blastomeres) is given in ng. In addition, cardiac beating was reduced upon Mef2c or Mef2d MO depletion. The dotted dark gray lines indicate the heart. a: atria; v: ventricle; oft: outflow tract. B, D. Quantitative presentations are shown. N: number of examined embryos; n: number of independent experiments. Image published in: Guo Y et al. (2014) Image reproduced on Xenbase with permission of the publisher and the copyright holder. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Larger Image Printer Friendly View |