Xenbase Image ID: 129802

Figure S5 Effects of XHMGA2 knockdown on cardiac, liver/thyroid, and endothelial marker gene expression. Whole-mount in situ hybridizations was performed at stage 34. a-c. XNkx2.5 expression in uninjected (a), MO1-injected (b), and MO2-injected embryos (c). XNkx2.5 expression was downregulated by XHMGA2 knockdown. d-f. Liver and thyroid gland development was verified by the expression of XHex in uninjected (d), MO1-injected (e), and MO2-injected embryos (f). Expression of the XHex mRNA was attenuated in liver (arrowhead) and lost in thyroid gland (asterisk) by XHMGA2 knockdown. g-i. Vascular formation was verified by the expression of Xmsr in uninjected (g), MO1-injected (h), and MO2- injected embryos (i). Vascular patterning was perturbed (asterisks) by XHMGA2 knockdown. Image published in: Monzen K et al. (2008) Copyright © 2008. Image reproduced with permission of the Publisher, Macmillan Publishers Ltd. Gene Synonyms Species Stage(s) Tissue nkx2-5.L AR2, csx, Nkx-2.5, nkx-2.5, nkx2-5-a, nkx2-5-b, nkx2.5, tinman, XNkx-2.5, XNkx2-5 X. laevis Throughout NF stage 33 and 34 heart cardiac mesoderm heart primordium visceral pouch hhex.L hex, tHex, XHex X. laevis Throughout NF stage 33 and 34 liver primordium thyroid primordium foregut endoderm aplnr.L agtrl1, angio1, apj, apjr, aplnr-a, aplnr-b, hg11, msr, X-msr, Xangio1, Xmsr X. laevis Throughout NF stage 33 and 34 blood vessel pharyngeal region head region dorsal aorta cardiovascular system Image source: Published Larger Image Printer Friendly View

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