Xenbase Image ID: 129907

Fig. 5. Ectopic expression of Xotx2 induces ectopic cement glands in the skin of developing embryos. (A) Xotx2 injected (left) and uninjected (right) embryos (stage 20). Note the induction of ectopic cement gland (arrow). (B) Xotx2-injected embryos (stage 22) are left and middle, and an uninjected embryo is right. Arrows indicate ectopic cement glands. (C) Xotx2-injected embryo grown until early tadpole stage. An ectopic cement gland is present in the ventral/lateral ectoderm. (D) Transverse section through head of normal tailbud stage embryo. Note that the normal cement gland shows characteristic columnar cells with dark pigmentation (arrow). (E) Transverse section through the trunk of an Xotx2- injected embryo. Box indicates the area of an ectopic cement gland. (F) High magnification view of the boxed area in E. Note the presence of characteristic columnar cells associated with pigment granules (arrow). (G) Incomplete blastopore closure resulting from injection of Xotx2 into a dorsal blastomere. Such embryos will later develop spina bifida. (H) Uninjected control embryo (top) and short-tail embryo (bottom) resulting from incomplete blastopore closure. Image published in: Blitz IL and Cho KW (1995) Copyright © 1995. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Larger Image Printer Friendly View

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