Xenbase Image ID: 129952

Figure 2. Lrp6 Apicobasal Asymmetry Requires Wnt/PCP Signaling (A–N) Confocal immunofluorescence microscopy of tagged (A–H, L, and M) or endogenous (I–K and N) proteins in blastulae. Embryos were injected with tagged LRP6, Dvl, or Par1T560A mRNAs and Morpholino oligonucleotides (MO) as indicated. Unless the color code is indicated, b1-integrin delineates the basolateral membrane in red. Dashed lines, apical membrane; arrowheads, cells with symmetric protein localization in green channel. Scale bar applies to all panels and represents 30 mm. (A0 ) LRP6 deletion constructs scheme. Experiments were typically carried out independently at least three times with similar results. For each experiment, more than ten embryos per sample were analyzed. See also Figure S2. Image published in: Huang YL and Niehrs C (2014) Copyright © 2014. Image reproduced with permission of the Publisher, Elsevier B. V. Larger Image Printer Friendly View

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