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Fig. 8. Depletion of β-catenin restores brain defects caused by MAK (hunk) MO. Embryos were injected with MAK MO (50 ng) and COMO (8 ng, A,C) or β-catenin MO (8 ng, B,D) into one dorsal animal blastomere at the four- to eight-cell stage. Whole-mount in situ hybridization of stage 19 embryos demonstrates that the effects of MAK MO on Otx2 and Gbx2 expression were partially reversed byβ -catenin MO (see also Table 2). Arrowheads in A and C indicate altered marker expression in MAK-depleted embryos. Nuclear βgal RNA served as a lineage tracer. Image published in: Kibardin A et al. (2006) Copyright © 2006. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Larger Image Printer Friendly View

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