Xenbase Image ID: 130292

Fig. S8. Genes involved in phenologs show enhanced interconnectivity in a gene network, shown here for yeast genes (10). All significant yeast-worm phenologs with at least four orthologs in both the “intersection” and “nonintersection” sets (SI Materials and Methods) were tested for network connectivity, measured as the area under a ROC plot as described in ref. 2, with values ranging from 0.5 (random network connectivity) to 1 (high network connectivity). Genes from phenolog intersections show significantly higher network connectivity than genes associated with a phenolog, but outside of the intersection, which in turn show significantly higher connectivity than size-matched random gene sets. Thus, phenologs capture subnetworks or network modules informative about a given phenotype pair, and carry predictive value for additional genes relevant to the phenotypes. At the left of each box-and-whisker plot, the center of the blue diamond indicates the mean AUC across phenologs, the top and bottom of the diamond indicate the 95% confidence interval, and the accompanying solid vertical line indicates ± 2 SD. The bottom, middle, and top horizontal lines of the box-and-whisker plots represent the first quartile, the median, and the third quartile of AUCs, respectively; whiskers indicate 1.5 times the interquartile range. Red plus signs represent individual outliers. Image published in: McGary KL et al. (2010) Copyright © 2010. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Larger Image Printer Friendly View

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