Xenbase Image ID: 130404

Figure 5. Mad Is Epistatic to Wg Signaling During Neurogenic Induction.(A) Mad was phosphorylated at its MAPK sites in developing CNS neuroblasts. (B) pMadCter was excluded from the neurogenic ectoderm marked by SoxNeuro (stage 8). (C and D) Mad RNAi driven in the egg by pUASp knocked down pMadMAPK staining (stage 7). (E and F) Maternal Mad RNAi knocked down pMADMAPK centrosomal staining (stage 7, see Figure S5 for asymmetric centrosomal staining). (G–J) Mad RNAi increased neurogenic ectodermal nuclei marked by SoxNeuro at stage 8, Wg overexpression reduced it, and the double Wg;RNAi embryos displayed the Mad depletion phenotype. All images were taken at identical exposure conditions. This experiment shows that Mad is epistatic to Wg. Image published in: Eivers E et al. (2009) Eivers et al. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Larger Image Printer Friendly View

Return to previous page