XB-IMG-130405
Xenbase Image ID: 130405
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Figure 6. Mad Is Required for Segmentation in Drosophila.(A–B) Early depletion of Mad caused wider (ventralized) denticle belts and internalized posterior spiracles in embryonic cuticles (n = 259 cuticles, 20% ventralized and 34% ventralized with denticle belt fusions). (C and C') Denticle belt fusions showing large (row 5-like) denticles. (D and D') Wg loss-of-function caused a ventral lawn of denticles. Note that these are large denticles with a small refringent spot (row 5 denticles) resembling those seen in Mad RNAi depletion. (E) DppH46 mutant embryo showing fusion of two denticle belts. (F and F') Overexpression of UAST-MGM driven by mat-Gal4-VP16 caused patches of naked cuticle at the expense of denticle rows. (G–I) Embryos stained for Engrailed at stage 9, showing that Mad depletion disrupts abdominal segmental bands, while MGM overexpression does not. Image published in: Eivers E et al. (2009) Eivers et al. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Larger Image Printer Friendly View |