Xenbase Image ID: 130451

Figure 1. dicky ticker maps to a lesion in the myosin co-chaperone unc45b. (A) Pools of gynogenetically derived wild type and dit embryos were assayed for linkage to polymorphisms near the 10 X. tropicalis chromosomes. Clear linkage (*) was observed at Linkage Group 6 (Chromosome 2) (B) Linkage analysis using SSLP and SNP markers with 562 mutant embryos placed the dit locus in a 230 kb interval of Scaffold_72 containing four gene models including unc45b. (C) cDNA sequence of dit unc45b revealed a thymidine to cytidine transition, substituting Arg for Cys779 in the UCS domain. (D) Cys779 is phylogenetically conserved in unc45b orthologs from Drosophila (Dm) to human (Hs). Image published in: Geach TJ and Zimmerman LB (2010) Copyright ©2010 Geach and Zimmerman; licensee BioMed Central Ltd. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Larger Image Printer Friendly View

Return to previous page