Xenbase Image ID: 130753

Fig. 7. a5h1 integrin is responsible for xPTP-PESTr-induced cell spreading on fibronectin. (A) Photographs of gastrula-stage animal cap ectoderm cells on FN (10 Ag/ml). Cells expressing GFP, the Wt- or C231S-PTP-PEST were seeded in the presence or absence of a function blocking mAb directed against integrin a5h1 (P8D4). (B) Histogram representing a quantitative analysis of the experiments presented in A. The error bars represent the standard deviation from the mean. The presence of P8D4 inhibits cell spreading induced by both the wild-type and C231S mutant forms of xPTPPEST to the same level as the GFP control ( P = 0.36). Image published in: Cousin H and Alfandari D (2004) Copyright © 2004. Image reproduced with permission of the Publisher, Elsevier B. V. Larger Image Printer Friendly View

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