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Xenbase Image ID: 130813

Fig. 1. Isolation of Xenopus BMP-3b and BMP-3 cDNAs. (A) Protein sequence comparison of Xenopus BMP-3b and BMP-3 with rat orthologues. Conserved amino acid residues in all four proteins are dotted and same amino acids within BMP-3b or BMP-3 are shaded. Dashes indicate spaces introduced to optimize alignment. Boxes represent cleavage sites; one is tetrabasic and the other is an alternative site determined by protein purification and N-terminal sequence analysis. GenBank Accession nos. for xBMP-3b and xBMP-3 are AB059564 and AB059563, respectively. (B) Phylogenetic relationships among complete precursors of human, zebrafish, and Xenopus BMP proteins. Dendrogram was generated by using the UPGMA method (GENETYX program, SDC Ltd, Japan). We used the underlined proteins (Figs. 5 and 6). Although ADMP is considered to be a BMP-3-like protein, it is more closely related to BMP-2 and BMP-4. XBMP-7 (Nishimatsu et al., 1992) has been renamed xBMP-7R, since a Xenopus orthologue of mammalian BMP-7 (OP-1) has been identified (Wang et al., 1997).

Image published in: Hino J et al. (2003)

Copyright © 2003. Image reproduced with permission of the Publisher, Elsevier B. V.

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