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Fig. 6. BMP-3b and BMP-3 differentially interact with TGF- family members. Synthetic mRNAs for BMP-2 (A), ADMP (B), Xnr1 (C), derrie`re (D), and caALK4 receptor (E) were injected into animal caps and their mesoderminducing activities were challenged by increasing doses of BMP-3b or BMP-3. Combinations and doses (pg) of each mRNA sample are indicated above lanes. Animal caps were harvested at stage 12 for scoring by RT-PCR. Brachyury (XBra) and NCAM served as pan-mesodermal and pan-neural markers, respectively. A 25-fold excess of BMP-3b (*) interfered with Xbra expression by all ligands, whereas BMP-3 reduced expression induced by BMP-2 and ADMP. Both of BMP-3b and BMP-3 alone induced NCAM expression in animal caps (A), indicating that they are neural inducers. Image published in: Hino J et al. (2003) Copyright © 2003. Image reproduced with permission of the Publisher, Elsevier B. V. Larger Image Printer Friendly View

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