XB-IMG-130838
Xenbase Image ID: 130838
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FIG. 2. Transcription factors (green) and signaling proteins (blue, yellow) that function within recently elucidated pathways of early
endoderm differentiation in X. laevis (left) and D. rerio (right). Maternal (top) and zygotic (bottom) determinants are indicated, and the
progressive commitment of mesendodermal progenitors to endodermal cell fate is depicted as a continuum in the gray bar to the left. Solid
arrows indicate experimental evidence for induction or genetic interaction, whereas dotted arrows point to likely but yet unproven
relationships. To date, only a single Mix-like transcription factor, bonnie and clyde (bon), is implicated genetically in zebrafish endoderm
formation, in contrast to a panoply of related Mix proteins in Xenopus. Vg1 is a Xenopus TGF ligand not discussed in this review.
Orthologs for Xenopus Veg T and zebrafish casanova remain unidentified. The transcription factors shown probably function cell
autonomously; although the secreted proteins act on cells neighboring those that release them, autocrine action on producer cells
themselves is also likely. Image published in: Shivdasani RA (2002) Copyright © 2002. Image reproduced with permission of the Publisher, Elsevier B. V. Larger Image Printer Friendly View |