Xenbase Image ID: 131157

Fig. 5. Hes6 promotes neuronal differentiation. (A-H) Two-cell-stage embryos were injected with Hes6 RNA along with lacZ RNA as a tracer. Embryos were fixed and stained with X-gal at neural plate stages and then processed for the staining for probes that correspond to various genes expressed during primary neurogenesis as indicated. Hes6 induces an increase in the number of cells expressing Xmyt1 (11/15 embryos), Drebrin (8/9), Nscl1 (10/10), Xmmot-1 (12/13), Elrc (11/11), N-tubulin 90/108), Xngn1 (15/17) and Xaml (10/10). (I,J) For comparison, embryos were injected with RNA encoding a dominant negative form of Su(H), XSu(H)DBM, and stained with probes of N-tubulin and Xngn1 (Wettstein et al., 1997). Note that the levels of Xngn1 increase on the injected side, but the striped pattern of expression is retained, and that N-tubulin-expressing cells subsequently form at a higher density in each stripe. Image published in: Koyano-Nakagawa N et al. (2000) Copyright © 2000. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Larger Image Printer Friendly View

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