XB-IMG-131198
Xenbase Image ID: 131198
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Fig. 1. pitx2 isoforms are conserved in vertebrate evolution. (A) The human pitx2 gene uses two promoters (arrows) to generate pitx2a and
pitx2c isoforms that differ in their coding potential in 5¢ regions (Arakawa et al., 1998). The zebrafish genomic structure is unknown. Here, the
Pitx2 proteins predicted from cDNA sequences are compared across vertebrate species; conservation of the amino acid sequence for both
zebrafish isoforms suggests a genomic structure similar to that in humans. Black boxes represent regions encoding homeodomain. (B) The
zebrafish (z) Pitx2a unique region compared to Pitx2a from mouse (m), the human (h) Pitx2a homolog, Arp1a, and Xenopus (xl) Pitx2b. The
nomenclature of the Xenopus isoforms does not conform with the nomenclature of other species. (C) The zebrafish Pitx2c unique region
compared to a similar region in other species including chicken (c). (D) The bicoid-like homeodomain and C-terminal region of zebrafish Pitx2
compared to Pitx2 from other species. The homeodomain region is underlined. Dark gray boxes show regions of identity, while light gray show
conservative amino acid substitutions. Image published in: Essner JJ et al. (2000) Copyright © 2000. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Larger Image Printer Friendly View |