XB-IMG-131200
Xenbase Image ID: 131200
Fig. 8. Model of genetic interactions involving pitx2 isoforms during
early mesendoderm and prechordal plate development in zebrafish.
Red arrows indicate associations deduced from analysis of mutant
zebrafish embryos. Blue arrows show relationships where increased
expression of pitx2 isoforms induces ectopic expression of targets.
Green lines represent negative regulation of endogenous expression
as a result of ectopic expression. Black lines indicate decisions in cell
fate. (A) Regulation of pitx2c. (B) Regulation of pitx2a. Antagonistic
interactions between cyc and lft and lft regulation of pitx2 were
shown by Bisgrove et al. (1999). In addition to showing that pitx2c is
reduced in cyc and oep mutants (this study; blue arrow), the
regulation of pitx2 by ectopic expression of nodal (Xnr1 in Xenopus
or cyc in fish) was shown by Campione et al. (1999) (red arrow). Image published in: Essner JJ et al. (2000) Copyright © 2000. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Larger Image Printer Friendly View |