XB-IMG-131453
Xenbase Image ID: 131453
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FIG. 1. BMP4 expression during early heart morphogenesis. Whole-mount in situ hybridisation to endogenous BMP4 RNA at stages 30
(A), 33 (E), and 35 (I). (B, C, and D) Transverse sections through the anterior, middle, and posterior, respectively, of the heart tube of the stage
30 embryo pictured in A. The future cardiac tissue is present as a layer under the ventral surface of the embryo. BMP4 expression is uniform
along the left–right axis at this stage. (F, G, and H) Transverse sections through the anterior, middle, and posterior, respectively, of the heart
tube of the stage 33 embryo pictured in E. Note that at this stage the cardiac tissue forms a tube at the posterior end (H). Furthermore BMP4
expression is asymmetric, being present more on the left side of the tube than the right (H). (J, K, and L) Transverse sections through the
anterior, middle, and posterior, respectively, of the heart tube of the stage 35 embryo pictured in I. Note that BMP4 expression is detected
throughout the heart precursor, predominantly in the dorsal area of the presumptive atrium (a) and ventricle (v). (N) A longitudinal section
through the heart region of a stage 32 embryo. Note the predominantly left-sided expression of BMP4 in the posterior region of the heart
(red arrow). (O) An enlargement of the region in H demarked by a dotted square. Dotted lines in A, E, I, and M correlate with the respective
plane of sections in B–D, F–H, J–L, and N. Image published in: Breckenridge RA et al. (2001) Copyright © 2001. Image reproduced with permission of the Publisher, Elsevier B. V. Larger Image Printer Friendly View |