Xenbase Image ID: 131467

Fig. 5. Geminin inhibits expression of the epidermalizing growth factor BMP4 in ventral and lateral ectoderm during gastrulation. BMP4 expression (in aqua) occurs in lateral and ventral ectoderm of uninjected embryos (A) but is eliminated by injection of 250 pg Ngem RNA (pink staining B,C). A and B are lateral views; C is an animal hemisphere view; embryos are stage 12 and dorsal is to the right. (D) BMP4 expression is downregulated in ectoderm injected with Ngem RNA. Expression of endogenous geminin is induced by injected Ngem (primers recognize the 3¢ untranslated region not included in the injected RNA). Muscle actin is not induced by geminin. Image published in: Kroll KL et al. (1998) Copyright © 1998. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Larger Image Printer Friendly View

Return to previous page