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Xenbase Image ID: 131710

Fig. 7. Brat is induced by peptide growth factors in the FGF and TGF-b families. (A) Brat displays dose-dependent induction by FGF or activin protein. Animal caps were excised at stage 8-9 and exposed to the indicated concentrations of FGF or activin protein. Caps were harvested at stage 11, and Brat induction was analyzed on a northern blot. RNA recovery was equal across the blot (not shown). (B) Brat is induced by BVg1 and BMP-4. Caps were injected with 30 pg of BVg1 mRNA or 1.8 ng BMP-4 mRNA, excised at stage 9, harvested at stage 11, and scored for Brat expression by RT-PCR. EF1-alpha expression is a control for RNA recovery and cDNA synthesis. Maternal Brat transcripts in the animal pole (see Fig 2c) account for the background signal in vector-injected animal caps.

Image published in: Horb ME and Thomsen GH (1997)

Copyright © 1997. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License.

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