XB-IMG-131866
Xenbase Image ID: 131866
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Figure 5. mRNA and Protein Abundance
(A) Histogram of mRNA levels in the egg. mRNA for which the protein was also detected is colored blue. Orange indicates that only mRNA was detected. The
median of mRNA concentration is approximately 1,000-fold lower than the median for protein abundance. Although we see only a weak correlation between
mRNA and protein abundance (0.32 Pearson correlation), the lower the mRNA concentration, the less likely we are to detect the corresponding protein.
(B) mRNA and protein were matched via assigned gene symbols. MS is able to identify approximately 60% of all gene symbols for which we could detect
mRNA. The proteins that we cannot detect via MS are overrepresented by transcription factors, proteins involved in differentiation, and transmembrane
proteins. On the contrary, for w350 gene symbols, we could identify only proteins, but not mRNA. This group is highly enriched for blood plasma and liver
proteins and was likely endocytosed during oocyte growth. Image published in: Wühr M et al. (2014) Copyright © 2014. Image reproduced with permission of the Publisher, Elsevier B. V. Larger Image Printer Friendly View |