Xenbase Image ID: 132004

FIG. 1. The amino acid sequence predicted from Xlefty is conserved in vertebrate evolution. The amino acid sequences of Xenopus (X) Lefty-a and Lefty-b are compared to zebrafish (z) Lefty1 and 2, chick (c) Lefty, mouse (m) Lefty1 and 2, and human (h) LEFTY A and B. Light gray shading represents conservative amino acid substitutions, and medium gray indicates amino acid identity. Putative cleavage sites, with RXXR consensus sequence, and conserved cysteines, predicted to form the characteristic cysteine knot of the TGFb superfamily, are shown in black. The position of the missing cysteine in the Lefty subfamily is indicated with an arrow. Image published in: Branford WW et al. (2000) Copyright © 2000. Image reproduced with permission of the Publisher, Elsevier B. V. Larger Image Printer Friendly View

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