Xenbase Image ID: 132097

Fig. 3. Model for the interactions between proneural and neurogenic genes during primary neurogenesis in Xenopus. Diagrams in A and B represent potential interactions between proneural and neurogenic genes within cells of the neural plate where primary neurons are generated. In A, proneural genes expression promotes neuronal differentiation, but also promotes the expression of X-Delta-1. The expression of X-Delta-1 activates Notch in neighboring cells as shown in B, which blocks the ability of proneural genes to activate Delta in these cells. These interactions produce a negative feedback loop which allows the cell in A to express NeuroD, at which point it undergoes neuronal differentiation. Conversely, the cell in B cannot turn on NeuroD because of Notch activation, and thus fails to differentiate. Image published in: Chitnis A and Kintner C (1996) Copyright © 1996. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Larger Image Printer Friendly View

Return to previous page