Xenbase Image ID: 132714

FIGURE 1. Characterization and expression analysis of Xenopus GDF5. A, dendrogram showing the phylogenetic relationship between members of the GDF5, -6, -7, and -16 subfamily. Full-length amino acid sequences were analyzed using GeneWorks® Version 2.2 (IntelliGenetics, Inc.) software. B, amino acid sequence comparison of full-length human, mouse, and Xenopus GDF5. Sequence identities are boxed; sequence similarities are highlighted in gray. C, RT-PCR analysis for Xenopus GDF5 using RNA obtained from indicated stages of Xenopus development (h = hindlimb; f = forelimb). D, whole mount hybridization in situ of Xenopus GDF5 of a stage 59 Xenopus forelimb. Arrows indicate the location of positive signal at presumptive joint interzones. Image published in: Thomas JT et al. (2006) Copyright © 2006. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Gene Synonyms Species Stage(s) Tissue gdf5.L CDMP1, gdf, gdf-5 X. laevis Throughout NF stage 59 hand joint region forelimb cartilage tissue Image source: Published Larger Image Printer Friendly View

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