Xenbase Image ID: 133447

FIGURE 9. A model for the function of Xdpcp to regulate activin/nodal signaling during embryogenesis. A, in the presence of Xdpcp, it inhibits activin/nodal signaling by masking the receptor to inhibit the contact of Smad2 to the receptor, thereby inhibiting the phosphorylation and nuclear translocation of Smad2 protein. B, in the Xenopus embryo, Xdpcp in the animal region inhibits the mesoderm inducing signals such as activin/nodal signaling from the vegetal region. Image published in: Cheong SM et al. (2009) Copyright © 2009. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Larger Image Printer Friendly View

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