Xenbase Image ID: 133473

Lee et al. Supplemental Figure 2. The 14 Biochemical Reactions Included in the Mathematical Model. For each reaction the name and value of its biochemical parameters are shown. We estimated the D-V circumference of the Xenopus gastrula embryo to be 4400 μm and Chordin to be expressed in the dorsal 30% of the embryo (700 μm). BMP4 and Tld/BMP1 were assumed to be expressed uniformly in the early embryo. The diffusion constant for Chd (DChd), BMP (DBMP), and ChdBMP (DChdBMP) was set to D=102 μm2.s-1, and to 0 μm2.s-1 for the other molecular species; relevant references for these parameters are listed in the figure. The initial concentrations of the different components were set between 0.3 and 1.0 nM for Tld, between 5 and 10 nM for the BMP receptor complex (BMPR), and at 0 nM for the rest. The concentrations of each molecular species were allowed to evolve for 2 hours, which represents the time taken by the Xenopus embryo to develop from late blastula to early gastrula. Image published in: Lee HX et al. (2009) Copyright © 2009. Image reproduced on with permission of the Publisher, Cold Spring Harbor Laboratory Press. This is an Open Access article. Larger Image Printer Friendly View

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