Xenbase Image ID: 133616

Figure 4 Photoreceptor rosettes in retinas deficient for Pax6 (A), mNcad (B), Ncad (C), and NCAM (D). Cryostat sections and confocal microscopy of Stage 42 tadpoles using antiserum to photoreceptors (red) and monoclonal antibody to vimentin (green) to reveal radial glia. A: Mu ̈ller cell endfeet (arrowheads) directed toward the RPE layer (arrows), indicating the presence of a second retina in mir- ror orientation. B: Rosette (arrowhead) and a corresponding gap (arrows) in the photoreceptor layer suggesting displace- ment of outer into inner retina. C: Heavy disruption of photoreceptor layer (arrows) and rosette formation (arrow- heads). D: Numerous rosettes (arrowheads) and Mu ̈ller cell endfeet (arrow) in the outer retina. Bar, 50 um. Image published in: Rungger-Brändle E et al. (2010) Copyright © 2010. Image reproduced with permission of the Publisher, John Wiley & Sons. Larger Image Printer Friendly View

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