Xenbase Image ID: 133669

Fig. 1. A gradient of BMP activity patterns the D-V axis of the Xenopus gastrula. (A) BMP activity along the D-V axis results from a series of direct protein–protein interactions between Chordin and other partners (black arrows), transcriptional regulation (blue arrows), and protein flux (red arrows). The entire embryo participates in forming the BMP gradient, which results from the dueling activities of the dorsal and ventral signaling centers. (B) Transverse optical section at gastrula (stage 11) showing a ventral- (V) to-dorsal (D) gradient of BMP activity using anti-pSmad1/5/8 antibody as readout. (C) Gastrula (stage 11) embryo sectioned sagittally, showing higher BMP activity in the ventral animal cap and marginal zone nuclei as assessed by pSmad1/5/8 immunostaining. Image published in: Plouhinec JL et al. (2013) Copyright © 2013. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Larger Image Printer Friendly View

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