Xenbase Image ID: 134418

Figure 1. Comparative Alignments of the Newly Identified Precursors with Known Amphibian CCK, Gastrin, and Caerulein Precursors (A) Amino acid sequence alignment of the S. tropicalis XT-6 like precursor (XT6LP) with amphibian CCK precursors and an X. laevis caerulein precursor (XLCAE3P). The sequence of XLCAE3P occupies multiple lines because duplicated exons were aligned to each other. Numbers in parentheses indicate XLCAE3LP exon ends. (B) Gene structure comparison of the xt6lp gene with the cck and xlcae3p genes. (C) Amino acid sequence alignment of the Litoria splendida caerulein 1 precursor (LSCAE1P) with amphibian gastrin. The newly identified precursors are labeled in lime green. In (A) and (C), amino acid residues are highlighted as follows: dark gray, shared between caerulein precursors and others; light gray, shared between XT6LP and CCK precursors; orange, XT-6 isoform; blue, caerulein peptides. Predicted signal peptides are printed in lowercase. In (B), homologous exons and peptide regions are shown in the same color scheme. SP indicates signal peptide. Image published in: Roelants K et al. (2010) Copyright © 2010. Image reproduced with permission of the Publisher, Elsevier B. V. Larger Image Printer Friendly View

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