XB-IMG-134419
Xenbase Image ID: 134419
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Figure 2.
Phylogeny and Comparative Genomics of the Vertebrate cck/gastrin Gene Family
Left: parallel origins of caerulein are indicated in light blue. Inferred duplication events are labeled “D.” Branch labels represent bootstrap percentages obtained by maximum parsimony (left) and maximum likelihood (right); values < 50% are indicated by a slash (/). Gray and black bootstrap percentages are calculated from data sets 1 and 2, respectively (see Results). The phylogeny is time calibrated with a Bayesian relaxed-clock model and priors for vertebrate divergence times derived from the fossil record and molecular studies (see Supplemental Experimental Procedures). Black horizontal bars in the timescale represent 95% credibility intervals for two relevant duplication events (nodes D1 and D2). Branches along which skin expression evolved are indicated in orange. Right: cck and gastrin genes of various vertebrates and xt6lp of S. tropicalis (filled and empty dark green symbols in the synteny maps) are flanked by homologous gene pairs (vertically aligned filled and empty symbols; see gene identity legend for color code), providing evidence for a segmental duplication (node D1) in the ancestor of jawed vertebrates. Depicted genes were included in data set 2. The following abbreviations are used: Np, Neoproterozoic; Cz, Cenozoic; CI, credibility interval; Mya, million years ago; Chr, chromosome; Scaff, scaffold. Image published in: Roelants K et al. (2010) Copyright © 2010. Image reproduced with permission of the Publisher, Elsevier B. V. Larger Image Printer Friendly View |