Xenbase Image ID: 134706

Fig. 7. Genes with altered expression in rax mutants include those necessary for retina formation and forebrain patterning. (A) Table listing key up-regulated (red) and down-regulated (blue) genes from RNA-Seq analysis. (All significantly affected genes identified in this analysis can be found in Table S4) (B) In situ hybridization for up-regulated genes in St. 15 embryos. White arrows indicate regions where up-regulation is observed in mutants in the presumptive retinal field. (C) In situ hybridization for down-regulated genes in St. 15 embryos. White arrows indicate regions in the eye field where expression is not detected in the mutant. (D) vsx1 expression (arrows) at neural plate stage is reduced in the heterozygote compared to wildtype and not detected in rax homozygous mutant embryos. (E) A time course of fezf2 and hesx1 expression from late gastrula (St. 12) through neural tube stage (St. 21) in rax mutant and wildtype embryos. White arrows indicate regions where repression is seen in wildtype embryos and not observed in rax mutants. Image published in: Fish MB et al. (2014) Copyright © 2014. Image reproduced with permission of the Publisher, Elsevier B. V. Gene Synonyms Species Stage(s) Tissue fezf2 X. tropicalis Sometime during NF stage 13 to NF stage 21 pre-chordal neural plate optic vesicle eye primordium optic field hesx1 anf2, hesx1-a, hesx1-b, rpx, Xanf, Xanf-1, XANF-2, Xanf1, Xanf2 X. tropicalis Sometime during NF stage 13 to NF stage 21 pre-chordal neural plate optic vesicle eye primordium optic field hesx1 anf2, hesx1-a, hesx1-b, rpx, Xanf, Xanf-1, XANF-2, Xanf1, Xanf2 X. tropicalis Throughout NF stage 15 pre-chordal neural plate optic vesicle eye primordium fzd4 frizzled 4, frizzled-4, frizzled4, Fz-4, Fz4, LOC108708760, Xfz4 X. tropicalis Throughout NF stage 15 pre-chordal neural plate optic vesicle neural tube eye primordium myc c-myc, cmyc, myc-a, myc-b, X-cmyc, Xcmyc X. tropicalis Throughout NF stage 15 pre-chordal neural plate optic vesicle eye primordium chordal neural plate border neural plate border pre-chordal neural plate border myb c-myb, cmyb, xmyb X. tropicalis Throughout NF stage 15 pre-chordal neural plate optic vesicle eye primordium foxn4 X. tropicalis Throughout NF stage 15 pre-chordal neural plate optic vesicle eye primordium mab21l2 mab21l2-a, mab21l2-b, Mab21l2b, Xmab-21, xmab21, xmab21l2 X. tropicalis Throughout NF stage 15 pre-chordal neural plate optic vesicle eye primordium presumptive midbrain-hindbrain boundary vsx1 ktcn, ppcd, ppd, rinx, Xvsx1 X. tropicalis Throughout NF stage 15 pre-chordal neural plate optic vesicle eye primordium Image source: Published Larger Image Printer Friendly View

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