Xenbase Image ID: 134831

Fig. 1 (Above). ClustalW alignment of translated Fmr1 gene from human, mouse, Xenopus, zebrafish and Drosophila. (A) The common motifs of FMRP conserved in all analyzed species are highlighted by colored boxes (orange: NLS, nuclear localization signal; red: KH1, K Homology domain 1; blue: KH2, K homology domain 2; green: NES, nuclear export signal; purple: RGG box). (B) Phylogenetic tree of FMRP sequences from above species constructed by DS Gene 1.5 program. The total number of differences between sequences is indicated by the scale bar and the bootstrap support values are shown at the node of the tree as a percentage. The amino acid sequences of human, mouse, Xenopus, zebrafish FMRP and Drosophila dFMR1 were obtained from GenBank database with accession numbers AAB18832, AAL66364, P51113, NP_694495 and AAF14639, respectively. Image published in: Lim JH et al. (2005) Copyright © 2005. Reproduced with permission of the Publisher, University of the Basque Country Press. Larger Image Printer Friendly View

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