Xenbase Image ID: 135402

Fig. 7. SU5402 treatment blocks pronephric primordium development by stage 22 but does not block glomeral development. (A, B) Control and SU5402 treated (from stage 15 to 22) embryos stained with lim1. SU5402 treatment has completely blocked lim1 expression in the pronephros. (C–F) Nephrin expression in controls and embryos treated with 50 μM SU5402 from stage 15 to 32. The glomus is abnormally shaped but is still present, as it is in embryos injected with hh. A second, previously unrecorded site of nephrin expression was observed in the branchial arches. This expression is also retained in SU5402-treated embryos but is in an abnormal position indicating an alteration in neural crest migration (red arrows). Panels E and F are enlarged views of the same embryos as shown in panels C and D. Image published in: Urban AE et al. (2006) Copyright © 2006. Image reproduced with permission of the Publisher, Elsevier B. V. Gene Synonyms Species Stage(s) Tissue lhx1.L lim-1, Lim1, lim1, Xlim-1, Xlim1 X. laevis Sometime during NF stage 15 to NF stage 22 pronephric mesenchyme nphs1.S nephrin X. laevis Throughout NF stage 29 and 30 pronephric kidney pharyngeal arch Image source: Published Larger Image Printer Friendly View

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