Xenbase Image ID: 135560

Fig. 2. Posterior Hox and PSM markers are reduced by RARγ-selective agonist and expanded by RARγ-selective inverse agonist. (A-F) WISH from embryos treated post-gastrulation (stage 12.5) with 10 nM 4647, 0.5 µM 5099 or vehicle (0.1% ethanol). Dashed red line represents half the embryo axis. 4647 diminishes and 5099 expands the expression of (A) Hoxd10 (4647, 16/16; 5099, 17/17 embryos), (B) Hoxc10 (4647, 14/14; 5099, 21/21), (C) Hoxc13 (4647, 12/12; 5099, 16/16), (D) Tbx6 (4647, 11/12; 5099, 17/17), (E) Msgn1 (4647, 15/15; 5099, 14/14), and (F) Rarγ2 (4647, 15/15; 5099, 9/9) relative to control vehicle. Embryos shown in lateral or dorsal view at tailbud stage, anterior to left. Image published in: Janesick A et al. (2014) Copyright © 2014. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Larger Image Printer Friendly View

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