Xenbase Image ID: 135666

Structural features of ESR-4 and ESR-5. (A)ESR-4 and ESR-5 encode closely related WRPW–bHLH proteins. The two bottom diagrams illustrate the mutant forms of ESR-5 that were generated by removing the basic domain, or by replacing the WRPW with the activation domain from Gal4. (B) Phylogenetic tree showing the sequence relationships of ESR-4 and ESR-5 to vertebrate WRPW–bHLH proteins recorded in the GenBank database, including those isolated from Xenopus, ESR-1/X–Hairy1/X-Hairy2A; zebrafish, zfHer1/ZfHer6; rat, rHES-1/rHES-2/rHES-3/rHES-5; chick: c-hairy1; and Drosophila, DmHairy1/Espl (m8). Image published in: Jen WC et al. (1999) Copyright © 1999. Image reproduced on with permission of the Publisher, Cold Spring Harbor Laboratory Press. This is an Open Access article. Larger Image Printer Friendly View

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