Xenbase Image ID: 135915

Figure 1. Truncated Wnt protein sequences. Alignment of the amino acid sequences for Dwnt-1 (wingless), mouse Wnt-1, and Xwnt-8. Periods represent gaps in the sequence alignment; the position of conserved cysteine residues are indicated by the letter C below the aligned sequences. The underlined letters represent the sequence of the truncated protein encoded by the Dwnt-1 mutant alleles $84 and CE7 and the amino acid sequence of dnWnt-1 and dnXwnt-8, truncated Wnt-1 and Xwnt-8 proteins, respectively, with dominant-negative activity. A truncation of Xwnt-8 at position 230, which results in a 30-amino-acid-shorter protein than dnXwnt-8, had only weak inhibitory activity. Image published in: Hoppler S et al. (1996) Copyright © 1996. Image reproduced on with permission of the Publisher, Cold Spring Harbor Laboratory Press. This is an Open Access article. Larger Image Printer Friendly View

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