Xenbase Image ID: 135988

Fig. 9. Comparison of Six1 expression in Xenopus with placodal fate maps (lateral views). A, B: Embryo labeled with DiI at the neural plate stage, which was subsequently analyzed by in situ hybridization for Six1. DiI injections (white arrows in A, black circles and arrows in B) are localized within the expression domain of Six1 (outlined by green line) and map well within the pre-placodal ectoderm in the fate map of neural plate stage embryos. C–H: The expression domains of Six1 (C, E, G and green encircled areas in D, F and H) at neural plate stages (C, D), at the end of neurulation (E, F) and in early tail bud stage embryos (G, H) were measured and compared to our fate maps. Six1 expression corresponds overall well to the distribution of placodal precursors in fate maps. However, at early stages, Six1 expression excludes most injections which contribute to the posterior lateral line placode and second/third vagal epibranchial placodes (D, F). These are localized within the expression domain of Six1 only from early tail bud stage on, indicating delayed upregulation of Six1 in these precursors (H). Conversely, Six1 is downregulated in the future lens placode from late neural fold stage on (E–H). Abbreviation: cg: cement gland. For detailed explanation of fate maps, see Figs. 6–8. Image published in: Pieper M et al. (2011) Copyright © 2011. Image reproduced with permission of the Publisher, Elsevier B. V. Larger Image Printer Friendly View

Return to previous page