Xenbase Image ID: 136032

Figure 1. Fgfr signaling during the eye field stage, but not later, is critical for proper eye morphogenesis. A–C: Lateral wholemount views of the head and enlarged eye of Stage-40 Xenopus laevis embryos incubated in a control DMSO solution (A) or 150–200 μM solution of the Fgfr inhibitor, SU5402, for 5 hr beginning at developmental Stage 12 (B) or continuously from Stage 24 through to Stage 40 (C). Red arrows point to the choroid fissure. D: The percentage of eyes exhibiting a gap (i.e. coloboma) of the choroid fissure for the various inhibitor treatment groups. The black stripe indicates the time spent exposed to the Fgfr inhibitor solution, whereas the dashed line indicates time spent in 0.1× Marc's Modified Ringer solution. E: Lateral view of a Stage-40 embryo injected with δfgfr4a::gfp mRNA into D1.1 blastomeres at the 16-cell stage.Download figure to PowerPoint Image published in: Atkinson-Leadbeater K et al. (2014) Copyright © 2014. Image reproduced with permission of the Publisher, John Wiley & Sons. Larger Image Printer Friendly View

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