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FIGURE 5:. pH dependence of histone-binding affinity and phosphospecificity of class A and class B Survivins. (A) Differences in affinity of Survivin class A and class B toward H3T3ph(1-12) and H3(1-12) peptides depending on pH changes. Survivin class A is represented by hSurvivin, and Survivin class B is represented by xSurvivin. (B) Differences in phosphospecificity between Survivin class A (Homo sapiens) and class B (X. laevis) within pH range 6.8–8.2. Phosphospecificity is displayed as a ratio of the Survivin affinity to H3T3ph peptide to the affinity to H3 peptide, (1/KdH3T3ph)/(1/KdH3). Image published in: Niedzialkowska E et al. (2012) © 2012 Niedzialkowska et al. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike license Larger Image Printer Friendly View

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