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Fig. 10. Gene regulatory networks which yield bistability. (A) Mutual negative regulation between X and Y drives differentiation of a cell to express either X or Y, with the indirect repression of X by Y (via Z) being dispensible. (B) An alternative network, where the indirect repression of X by Y (via Z) is necessary to drive differentiation of a cell to express Y. Image published in: Brown LE et al. (2014) © 2014 The Authors. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Larger Image Printer Friendly View

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