XB-IMG-137170
Xenbase Image ID: 137170
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Figure 2. Defective prostatic epithelial differentiation was induced in the Bmpr1a-CKO mutants prostate. A, C, E, G, I, and K, Epithelial differentiation in the AP of control mice. B, D, F, H, J, and L, Epithelial differentiation in the AP of epithelial-specific Bmpr1a-CKO mutant mice. A and B, Costaining for green fluorescent protein (GFP) and pSmad1/5/8 in the AP at P14. Mosaic expression of GFP was detected only in the AP epithelia but not in the stroma of both control and Bmpr1a-CKO specimens (green). A and C, pSmad1/5/8 was localized primarily in the prostatic epithelia. B and D, Decreased pSmad1/5/8 expression was detected in the Bmpr1a-CKO specimens. E, Control AP ducts at P14. F, Bmpr1a-CKO mutant AP at P14. G and H, Histologic section of the control (G) and Bmpr1a-CKO mutant prostate (H). I–L, Costaining for K19 and K8 at P7 and P14. K, K19 was localized in basal epithelia and K8 was localized in the luminal epithelia of the control mouse prostate at P14 (K′, white arrows). K8 and K19 were aberrantly coexpressed at P14 in the Bmpr1a-CKO specimens (L). A–D and G and H, scale bars, 50 μm. I–L, scale bars, 20 μm. Image published in: Omori A et al. (2014) Copyright © 2014 by the Endocrine Society. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Larger Image Printer Friendly View |